Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson’s patients leukocytes
Identifieur interne : 000E11 ( Main/Exploration ); précédent : 000E10; suivant : 000E12Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson’s patients leukocytes
Auteurs : Lilach Soreq [Israël] ; Hagai Bergman [Israël] ; Zvi Israel [Israël] ; Hermona Soreq [Israël]Source :
- BMC Genomics [ 1471-2164 ] ; 2013.
English descriptors
- KwdEn :
- Alternative Splicing, Case-Control Studies, Deep Brain Stimulation, Disease Progression, Humans, Leukocytes (metabolism), Male, Models, Molecular, Nonsense Mediated mRNA Decay, Parkinson Disease (blood), Parkinson Disease (genetics), Parkinson Disease (therapy), Protein Conformation, RNA, Messenger (genetics).
- MESH :
- chemical , genetics : RNA, Messenger.
- blood : Parkinson Disease.
- genetics : Parkinson Disease.
- metabolism : Leukocytes.
- therapy : Parkinson Disease.
- Alternative Splicing, Case-Control Studies, Deep Brain Stimulation, Disease Progression, Humans, Male, Models, Molecular, Nonsense Mediated mRNA Decay, Protein Conformation.
Abstract
Nonsense-Mediated decay (NMD) selectively degrades mRNA transcripts that carry premature stop codons. NMD is often triggered by alternative splicing (AS) modifications introducing such codons. NMD plays an important regulatory role in brain neurons, but the
Here, we report exon arrays analysis of leukocyte mRNA AS events prior to and following Deep Brain Stimulation (DBS) neurosurgery, which efficiently improves the motor symptoms of Parkinson’s disease (PD), the leading movement disorder, and is increasingly applied to treat other diseases. We also analyzed publicly available exon array dataset of whole blood cells from mixed early and advanced PD patients. Our in-house exon array dataset of leukocyte transcripts was derived from advanced PD patients’ pre- and post-DBS stimulation and matched healthy control volunteers. The mixed cohort exhibited 146 AS changes in 136 transcripts compared to controls, including 9 NMD protein-level assessed events. In comparison, PD patients from our advanced cohort differed from healthy controls by 319 AS events in 280 transcripts, assessed as inducing 27 protein-level NMD events. DBS stimulation induced 254 AS events in 229 genes as compared to the pre-DBS state including 44 NMD inductions. A short, one hour electrical stimulus cessation caused 234 AS changes in 125 genes compared to ON-stimulus state, 22 of these were assessed for NMD. Functional analysis highlighted disease-induced DNA damage and inflammatory control and its reversal under ON and OFF stimulus as well as alternative splicing in all the tested states.
The study findings indicate a potential role for NMD both in PD and following electrical brain stimulation. Furthermore, our current observations entail future implications for developing therapies for PD, and for interfering with the impaired molecular mechanisms that underlie PD and other neurodegenerative and neurological disorders, as well as DBS-treatable conditions in general.
Url:
DOI: 10.1186/1471-2164-14-478
PubMed: 23865419
PubMed Central: 3723527
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000485
- to stream Pmc, to step Curation: 000485
- to stream Pmc, to step Checkpoint: 000680
- to stream PubMed, to step Corpus: 000890
- to stream PubMed, to step Curation: 000890
- to stream PubMed, to step Checkpoint: 000890
- to stream Ncbi, to step Merge: 001510
- to stream Ncbi, to step Curation: 001510
- to stream Ncbi, to step Checkpoint: 001510
- to stream Main, to step Merge: 000E23
- to stream Main, to step Curation: 000E11
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson’s patients leukocytes</title><author><name sortKey="Soreq, Lilach" sort="Soreq, Lilach" uniqKey="Soreq L" first="Lilach" last="Soreq">Lilach Soreq</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem 91904, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem 91904</wicri:regionArea><wicri:noRegion>Jerusalem 91904</wicri:noRegion></affiliation></author><author><name sortKey="Israel, Zvi" sort="Israel, Zvi" uniqKey="Israel Z" first="Zvi" last="Israel">Zvi Israel</name><affiliation wicri:level="1"><nlm:aff id="I3">Center for Functional & Restorative Neurosurgery, Department of Neurosurgery, Hadassah University Hospital, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Center for Functional & Restorative Neurosurgery, Department of Neurosurgery, Hadassah University Hospital, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Soreq, Hermona" sort="Soreq, Hermona" uniqKey="Soreq H" first="Hermona" last="Soreq">Hermona Soreq</name><affiliation wicri:level="1"><nlm:aff id="I2">The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem 91904, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem 91904</wicri:regionArea><wicri:noRegion>Jerusalem 91904</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">The Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23865419</idno><idno type="pmc">3723527</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723527</idno><idno type="RBID">PMC:3723527</idno><idno type="doi">10.1186/1471-2164-14-478</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000485</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000485</idno><idno type="wicri:Area/Pmc/Curation">000485</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000485</idno><idno type="wicri:Area/Pmc/Checkpoint">000680</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000680</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000890</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000890</idno><idno type="wicri:Area/PubMed/Curation">000890</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000890</idno><idno type="wicri:Area/PubMed/Checkpoint">000890</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000890</idno><idno type="wicri:Area/Ncbi/Merge">001510</idno><idno type="wicri:Area/Ncbi/Curation">001510</idno><idno type="wicri:Area/Ncbi/Checkpoint">001510</idno><idno type="wicri:Area/Main/Merge">000E23</idno><idno type="wicri:Area/Main/Curation">000E11</idno><idno type="wicri:Area/Main/Exploration">000E11</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson’s patients leukocytes</title><author><name sortKey="Soreq, Lilach" sort="Soreq, Lilach" uniqKey="Soreq L" first="Lilach" last="Soreq">Lilach Soreq</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem 91904, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem 91904</wicri:regionArea><wicri:noRegion>Jerusalem 91904</wicri:noRegion></affiliation></author><author><name sortKey="Israel, Zvi" sort="Israel, Zvi" uniqKey="Israel Z" first="Zvi" last="Israel">Zvi Israel</name><affiliation wicri:level="1"><nlm:aff id="I3">Center for Functional & Restorative Neurosurgery, Department of Neurosurgery, Hadassah University Hospital, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Center for Functional & Restorative Neurosurgery, Department of Neurosurgery, Hadassah University Hospital, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Soreq, Hermona" sort="Soreq, Hermona" uniqKey="Soreq H" first="Hermona" last="Soreq">Hermona Soreq</name><affiliation wicri:level="1"><nlm:aff id="I2">The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem 91904, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem 91904</wicri:regionArea><wicri:noRegion>Jerusalem 91904</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">The Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Genomics</title><idno type="eISSN">1471-2164</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alternative Splicing</term><term>Case-Control Studies</term><term>Deep Brain Stimulation</term><term>Disease Progression</term><term>Humans</term><term>Leukocytes (metabolism)</term><term>Male</term><term>Models, Molecular</term><term>Nonsense Mediated mRNA Decay</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (therapy)</term><term>Protein Conformation</term><term>RNA, Messenger (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alternative Splicing</term><term>Case-Control Studies</term><term>Deep Brain Stimulation</term><term>Disease Progression</term><term>Humans</term><term>Male</term><term>Models, Molecular</term><term>Nonsense Mediated mRNA Decay</term><term>Protein Conformation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Nonsense-Mediated decay (NMD) selectively degrades mRNA transcripts that carry premature stop codons. NMD is often triggered by alternative splicing (AS) modifications introducing such codons. NMD plays an important regulatory role in brain neurons, but the <italic>in vivo</italic> dynamics of AS and NMD changes in neurological diseases and under treatment were scarcely explored.</p></sec><sec><title>Results</title><p>Here, we report exon arrays analysis of leukocyte mRNA AS events prior to and following Deep Brain Stimulation (DBS) neurosurgery, which efficiently improves the motor symptoms of Parkinson’s disease (PD), the leading movement disorder, and is increasingly applied to treat other diseases. We also analyzed publicly available exon array dataset of whole blood cells from mixed early and advanced PD patients. Our in-house exon array dataset of leukocyte transcripts was derived from advanced PD patients’ pre- and post-DBS stimulation and matched healthy control volunteers. The mixed cohort exhibited 146 AS changes in 136 transcripts compared to controls, including 9 NMD protein-level assessed events. In comparison, PD patients from our advanced cohort differed from healthy controls by 319 AS events in 280 transcripts, assessed as inducing 27 protein-level NMD events. DBS stimulation induced 254 AS events in 229 genes as compared to the pre-DBS state including 44 NMD inductions. A short, one hour electrical stimulus cessation caused 234 AS changes in 125 genes compared to ON-stimulus state, 22 of these were assessed for NMD. Functional analysis highlighted disease-induced DNA damage and inflammatory control and its reversal under ON and OFF stimulus as well as alternative splicing in all the tested states.</p></sec><sec><title>Conclusions</title><p>The study findings indicate a potential role for NMD both in PD and following electrical brain stimulation. Furthermore, our current observations entail future implications for developing therapies for PD, and for interfering with the impaired molecular mechanisms that underlie PD and other neurodegenerative and neurological disorders, as well as DBS-treatable conditions in general.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bhuvanagiri, M" uniqKey="Bhuvanagiri M">M Bhuvanagiri</name></author><author><name sortKey="Schlitter, Am" uniqKey="Schlitter A">AM Schlitter</name></author><author><name sortKey="Hentze, Mw" uniqKey="Hentze M">MW Hentze</name></author><author><name sortKey="Kulozik, Ae" uniqKey="Kulozik A">AE Kulozik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hilleren, P" uniqKey="Hilleren P">P Hilleren</name></author><author><name sortKey="Parker, R" uniqKey="Parker R">R Parker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holbrook, Ja" uniqKey="Holbrook J">JA Holbrook</name></author><author><name sortKey="Neu Yilik, G" uniqKey="Neu Yilik G">G Neu-Yilik</name></author><author><name sortKey="Hentze, Mw" uniqKey="Hentze M">MW Hentze</name></author><author><name sortKey="Kulozik, Ae" uniqKey="Kulozik A">AE Kulozik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Wilkinson, Mf" uniqKey="Wilkinson M">MF Wilkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frischmeyer, Pa" uniqKey="Frischmeyer P">PA Frischmeyer</name></author><author><name sortKey="Dietz, Hc" uniqKey="Dietz H">HC Dietz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blaschke, Rj" uniqKey="Blaschke R">RJ Blaschke</name></author><author><name sortKey="Topfer, C" uniqKey="Topfer C">C Topfer</name></author><author><name sortKey="Marchini, A" uniqKey="Marchini A">A Marchini</name></author><author><name sortKey="Steinbeisser, H" uniqKey="Steinbeisser H">H Steinbeisser</name></author><author><name sortKey="Janssen, Jw" uniqKey="Janssen J">JW Janssen</name></author><author><name sortKey="Rappold, Ga" uniqKey="Rappold G">GA Rappold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moriarty, Pm" uniqKey="Moriarty P">PM Moriarty</name></author><author><name sortKey="Reddy, Cc" uniqKey="Reddy C">CC Reddy</name></author><author><name sortKey="Maquat, Le" uniqKey="Maquat L">LE Maquat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hillman, Rt" uniqKey="Hillman R">RT Hillman</name></author><author><name sortKey="Green, Re" uniqKey="Green R">RE Green</name></author><author><name sortKey="Brenner, Se" uniqKey="Brenner S">SE Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rebbapragada, I" uniqKey="Rebbapragada I">I Rebbapragada</name></author><author><name sortKey="Lykke Andersen, J" uniqKey="Lykke Andersen J">J Lykke-Andersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruno, Ig" uniqKey="Bruno I">IG Bruno</name></author><author><name sortKey="Karam, R" uniqKey="Karam R">R Karam</name></author><author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name></author><author><name sortKey="Bhardwaj, A" uniqKey="Bhardwaj A">A Bhardwaj</name></author><author><name sortKey="Lou, Ch" uniqKey="Lou C">CH Lou</name></author><author><name sortKey="Shum, Ey" uniqKey="Shum E">EY Shum</name></author><author><name sortKey="Song, Hw" uniqKey="Song H">HW Song</name></author><author><name sortKey="Corbett, Ma" uniqKey="Corbett M">MA Corbett</name></author><author><name sortKey="Gifford, Wd" uniqKey="Gifford W">WD Gifford</name></author><author><name sortKey="Gecz, J" uniqKey="Gecz J">J Gecz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, Bp" uniqKey="Lewis B">BP Lewis</name></author><author><name sortKey="Green, Re" uniqKey="Green R">RE Green</name></author><author><name sortKey="Brenner, Se" uniqKey="Brenner S">SE Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Cj" uniqKey="Lee C">CJ Lee</name></author><author><name sortKey="Irizarry, K" uniqKey="Irizarry K">K Irizarry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lykke Andersen, J" uniqKey="Lykke Andersen J">J Lykke-Andersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matlin, Aj" uniqKey="Matlin A">AJ Matlin</name></author><author><name sortKey="Clark, F" uniqKey="Clark F">F Clark</name></author><author><name sortKey="Smith, Cw" uniqKey="Smith C">CW Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, Q" uniqKey="Pan Q">Q Pan</name></author><author><name sortKey="Shai, O" uniqKey="Shai O">O Shai</name></author><author><name sortKey="Lee, Lj" uniqKey="Lee L">LJ Lee</name></author><author><name sortKey="Frey, Bj" uniqKey="Frey B">BJ Frey</name></author><author><name sortKey="Blencowe, Bj" uniqKey="Blencowe B">BJ Blencowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Wk" uniqKey="Chan W">WK Chan</name></author><author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name></author><author><name sortKey="Gudikote, Jp" uniqKey="Gudikote J">JP Gudikote</name></author><author><name sortKey="Chang, Yf" uniqKey="Chang Y">YF Chang</name></author><author><name sortKey="Imam, Js" uniqKey="Imam J">JS Imam</name></author><author><name sortKey="Maclean, Ja" uniqKey="Maclean J">JA MacLean</name></author><author><name sortKey="Wilkinson, Mf" uniqKey="Wilkinson M">MF Wilkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saltzman, Al" uniqKey="Saltzman A">AL Saltzman</name></author><author><name sortKey="Pan, Q" uniqKey="Pan Q">Q Pan</name></author><author><name sortKey="Blencowe, Bj" uniqKey="Blencowe B">BJ Blencowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcilwain, Dr" uniqKey="Mcilwain D">DR McIlwain</name></author><author><name sortKey="Pan, Q" uniqKey="Pan Q">Q Pan</name></author><author><name sortKey="Reilly, Pt" uniqKey="Reilly P">PT Reilly</name></author><author><name sortKey="Elia, Aj" uniqKey="Elia A">AJ Elia</name></author><author><name sortKey="Mccracken, S" uniqKey="Mccracken S">S McCracken</name></author><author><name sortKey="Wakeham, Ac" uniqKey="Wakeham A">AC Wakeham</name></author><author><name sortKey="Itie Youten, A" uniqKey="Itie Youten A">A Itie-Youten</name></author><author><name sortKey="Blencowe, Bj" uniqKey="Blencowe B">BJ Blencowe</name></author><author><name sortKey="Mak, Tw" uniqKey="Mak T">TW Mak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kringelbach, Ml" uniqKey="Kringelbach M">ML Kringelbach</name></author><author><name sortKey="Jenkinson, N" uniqKey="Jenkinson N">N Jenkinson</name></author><author><name sortKey="Owen, Sl" uniqKey="Owen S">SL Owen</name></author><author><name sortKey="Aziz, Tz" uniqKey="Aziz T">TZ Aziz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fahn, S" uniqKey="Fahn S">S Fahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoehn, Mm" uniqKey="Hoehn M">MM Hoehn</name></author><author><name sortKey="Yahr, Md" uniqKey="Yahr M">MD Yahr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deuschl, G" uniqKey="Deuschl G">G Deuschl</name></author><author><name sortKey="Schade Brittinger, C" uniqKey="Schade Brittinger C">C Schade-Brittinger</name></author><author><name sortKey="Krack, P" uniqKey="Krack P">P Krack</name></author><author><name sortKey="Volkmann, J" uniqKey="Volkmann J">J Volkmann</name></author><author><name sortKey="Schafer, H" uniqKey="Schafer H">H Schafer</name></author><author><name sortKey="Botzel, K" uniqKey="Botzel K">K Botzel</name></author><author><name sortKey="Daniels, C" uniqKey="Daniels C">C Daniels</name></author><author><name sortKey="Deutschlander, A" uniqKey="Deutschlander A">A Deutschlander</name></author><author><name sortKey="Dillmann, U" uniqKey="Dillmann U">U Dillmann</name></author><author><name sortKey="Eisner, W" uniqKey="Eisner W">W Eisner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pollak, P" uniqKey="Pollak P">P Pollak</name></author><author><name sortKey="Fraix, V" uniqKey="Fraix V">V Fraix</name></author><author><name sortKey="Krack, P" uniqKey="Krack P">P Krack</name></author><author><name sortKey="Moro, E" uniqKey="Moro E">E Moro</name></author><author><name sortKey="Mendes, A" uniqKey="Mendes A">A Mendes</name></author><author><name sortKey="Chabardes, S" uniqKey="Chabardes S">S Chabardes</name></author><author><name sortKey="Koudsie, A" uniqKey="Koudsie A">A Koudsie</name></author><author><name sortKey="Benabid, Al" uniqKey="Benabid A">AL Benabid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hawkes, Ch" uniqKey="Hawkes C">CH Hawkes</name></author><author><name sortKey="Del Tredici, K" uniqKey="Del Tredici K">K Del Tredici</name></author><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author><author><name sortKey="Del Tredici, K" uniqKey="Del Tredici K">K Del Tredici</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Obeso, Ja" uniqKey="Obeso J">JA Obeso</name></author><author><name sortKey="Rodriguez Oroz, Mc" uniqKey="Rodriguez Oroz M">MC Rodriguez-Oroz</name></author><author><name sortKey="Goetz, Cg" uniqKey="Goetz C">CG Goetz</name></author><author><name sortKey="Marin, C" uniqKey="Marin C">C Marin</name></author><author><name sortKey="Kordower, Jh" uniqKey="Kordower J">JH Kordower</name></author><author><name sortKey="Rodriguez, M" uniqKey="Rodriguez M">M Rodriguez</name></author><author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name></author><author><name sortKey="Farrer, M" uniqKey="Farrer M">M Farrer</name></author><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name></author><author><name sortKey="Halliday, G" uniqKey="Halliday G">G Halliday</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scherzer, Cr" uniqKey="Scherzer C">CR Scherzer</name></author><author><name sortKey="Eklund, Ac" uniqKey="Eklund A">AC Eklund</name></author><author><name sortKey="Morse, Lj" uniqKey="Morse L">LJ Morse</name></author><author><name sortKey="Liao, Z" uniqKey="Liao Z">Z Liao</name></author><author><name sortKey="Locascio, Jj" uniqKey="Locascio J">JJ Locascio</name></author><author><name sortKey="Fefer, D" uniqKey="Fefer D">D Fefer</name></author><author><name sortKey="Schwarzschild, Ma" uniqKey="Schwarzschild M">MA Schwarzschild</name></author><author><name sortKey="Schlossmacher, Mg" uniqKey="Schlossmacher M">MG Schlossmacher</name></author><author><name sortKey="Hauser, Ma" uniqKey="Hauser M">MA Hauser</name></author><author><name sortKey="Vance, Jm" uniqKey="Vance J">JM Vance</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molochnikov, L" uniqKey="Molochnikov L">L Molochnikov</name></author><author><name sortKey="Rabey, Jm" uniqKey="Rabey J">JM Rabey</name></author><author><name sortKey="Dobronevsky, E" uniqKey="Dobronevsky E">E Dobronevsky</name></author><author><name sortKey="Bonucelli, U" uniqKey="Bonucelli U">U Bonucelli</name></author><author><name sortKey="Ceravolo, R" uniqKey="Ceravolo R">R Ceravolo</name></author><author><name sortKey="Frosini, D" uniqKey="Frosini D">D Frosini</name></author><author><name sortKey="Grunblatt, E" uniqKey="Grunblatt E">E Grunblatt</name></author><author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name></author><author><name sortKey="Jacob, C" uniqKey="Jacob C">C Jacob</name></author><author><name sortKey="Aharon Peretz, J" uniqKey="Aharon Peretz J">J Aharon-Peretz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martins, M" uniqKey="Martins M">M Martins</name></author><author><name sortKey="Rosa, A" uniqKey="Rosa A">A Rosa</name></author><author><name sortKey="Guedes, Lc" uniqKey="Guedes L">LC Guedes</name></author><author><name sortKey="Fonseca, Bv" uniqKey="Fonseca B">BV Fonseca</name></author><author><name sortKey="Gotovac, K" uniqKey="Gotovac K">K Gotovac</name></author><author><name sortKey="Violante, S" uniqKey="Violante S">S Violante</name></author><author><name sortKey="Mestre, T" uniqKey="Mestre T">T Mestre</name></author><author><name sortKey="Coelho, M" uniqKey="Coelho M">M Coelho</name></author><author><name sortKey="Rosa, Mm" uniqKey="Rosa M">MM Rosa</name></author><author><name sortKey="Martin, Er" uniqKey="Martin E">ER Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buttarelli, Fr" uniqKey="Buttarelli F">FR Buttarelli</name></author><author><name sortKey="Fanciulli, A" uniqKey="Fanciulli A">A Fanciulli</name></author><author><name sortKey="Pellicano, C" uniqKey="Pellicano C">C Pellicano</name></author><author><name sortKey="Pontieri, Fe" uniqKey="Pontieri F">FE Pontieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blake, Ci" uniqKey="Blake C">CI Blake</name></author><author><name sortKey="Spitz, E" uniqKey="Spitz E">E Spitz</name></author><author><name sortKey="Leehey, M" uniqKey="Leehey M">M Leehey</name></author><author><name sortKey="Hoffer, Bj" uniqKey="Hoffer B">BJ Hoffer</name></author><author><name sortKey="Boyson, Sj" uniqKey="Boyson S">SJ Boyson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krige, D" uniqKey="Krige D">D Krige</name></author><author><name sortKey="Carroll, Mt" uniqKey="Carroll M">MT Carroll</name></author><author><name sortKey="Cooper, Jm" uniqKey="Cooper J">JM Cooper</name></author><author><name sortKey="Marsden, Cd" uniqKey="Marsden C">CD Marsden</name></author><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soreq, L" uniqKey="Soreq L">L Soreq</name></author><author><name sortKey="Bergman, H" uniqKey="Bergman H">H Bergman</name></author><author><name sortKey="Israel, Z" uniqKey="Israel Z">Z Israel</name></author><author><name sortKey="Soreq, H" uniqKey="Soreq H">H Soreq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shehadeh, La" uniqKey="Shehadeh L">LA Shehadeh</name></author><author><name sortKey="Yu, K" uniqKey="Yu K">K Yu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Guevara, A" uniqKey="Guevara A">A Guevara</name></author><author><name sortKey="Singer, C" uniqKey="Singer C">C Singer</name></author><author><name sortKey="Vance, J" uniqKey="Vance J">J Vance</name></author><author><name sortKey="Papapetropoulos, S" uniqKey="Papapetropoulos S">S Papapetropoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soreq, L" uniqKey="Soreq L">L Soreq</name></author><author><name sortKey="Bergman, H" uniqKey="Bergman H">H Bergman</name></author><author><name sortKey="Goll, Y" uniqKey="Goll Y">Y Goll</name></author><author><name sortKey="Greenberg, Ds" uniqKey="Greenberg D">DS Greenberg</name></author><author><name sortKey="Israel, Z" uniqKey="Israel Z">Z Israel</name></author><author><name sortKey="Soreq, H" uniqKey="Soreq H">H Soreq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soreq, L" uniqKey="Soreq L">L Soreq</name></author><author><name sortKey="Salomonis, N" uniqKey="Salomonis N">N Salomonis</name></author><author><name sortKey="Bronstein, M" uniqKey="Bronstein M">M Bronstein</name></author><author><name sortKey="Greenberg, Ds" uniqKey="Greenberg D">DS Greenberg</name></author><author><name sortKey="Israel, Z" uniqKey="Israel Z">Z Israel</name></author><author><name sortKey="Bergman, H" uniqKey="Bergman H">H Bergman</name></author><author><name sortKey="Soreq, H" uniqKey="Soreq H">H Soreq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharp, Fr" uniqKey="Sharp F">FR Sharp</name></author><author><name sortKey="Jickling, Gc" uniqKey="Jickling G">GC Jickling</name></author><author><name sortKey="Stamova, B" uniqKey="Stamova B">B Stamova</name></author><author><name sortKey="Tian, Y" uniqKey="Tian Y">Y Tian</name></author><author><name sortKey="Zhan, X" uniqKey="Zhan X">X Zhan</name></author><author><name sortKey="Liu, D" uniqKey="Liu D">D Liu</name></author><author><name sortKey="Kuczynski, B" uniqKey="Kuczynski B">B Kuczynski</name></author><author><name sortKey="Cox, Cd" uniqKey="Cox C">CD Cox</name></author><author><name sortKey="Ander, Bp" uniqKey="Ander B">BP Ander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, Mc" uniqKey="De Wit M">MC de Wit</name></author><author><name sortKey="Lequin, Mh" uniqKey="Lequin M">MH Lequin</name></author><author><name sortKey="De Coo, If" uniqKey="De Coo I">IF de Coo</name></author><author><name sortKey="Brusse, E" uniqKey="Brusse E">E Brusse</name></author><author><name sortKey="Halley, Dj" uniqKey="Halley D">DJ Halley</name></author><author><name sortKey="Van De Graaf, R" uniqKey="Van De Graaf R">R van de Graaf</name></author><author><name sortKey="Schot, R" uniqKey="Schot R">R Schot</name></author><author><name sortKey="Verheijen, Fw" uniqKey="Verheijen F">FW Verheijen</name></author><author><name sortKey="Mancini, Gm" uniqKey="Mancini G">GM Mancini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Iv" uniqKey="Yang I">IV Yang</name></author><author><name sortKey="Wade, Cm" uniqKey="Wade C">CM Wade</name></author><author><name sortKey="Kang, Hm" uniqKey="Kang H">HM Kang</name></author><author><name sortKey="Alper, S" uniqKey="Alper S">S Alper</name></author><author><name sortKey="Rutledge, H" uniqKey="Rutledge H">H Rutledge</name></author><author><name sortKey="Lackford, B" uniqKey="Lackford B">B Lackford</name></author><author><name sortKey="Eskin, E" uniqKey="Eskin E">E Eskin</name></author><author><name sortKey="Daly, Mj" uniqKey="Daly M">MJ Daly</name></author><author><name sortKey="Schwartz, Da" uniqKey="Schwartz D">DA Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hosack, Da" uniqKey="Hosack D">DA Hosack</name></author><author><name sortKey="Dennis, G" uniqKey="Dennis G">G Dennis</name></author><author><name sortKey="Sherman, Bt" uniqKey="Sherman B">BT Sherman</name></author><author><name sortKey="Lane, Hc" uniqKey="Lane H">HC Lane</name></author><author><name sortKey="Lempicki, Ra" uniqKey="Lempicki R">RA Lempicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ayala, Ym" uniqKey="Ayala Y">YM Ayala</name></author><author><name sortKey="Laura De Conti, S" uniqKey="Laura De Conti S">S Laura De Conti</name></author><author><name sortKey="Vazquez, Ad" uniqKey="Vazquez A">AD Vázquez</name></author><author><name sortKey="Romano, M" uniqKey="Romano M">M Romano</name></author><author><name sortKey="D Mbrogio, A" uniqKey="D Mbrogio A">A D’Ambrogio</name></author><author><name sortKey="Tollervey, J" uniqKey="Tollervey J">J Tollervey</name></author><author><name sortKey="Ule, J" uniqKey="Ule J">J Ule</name></author><author><name sortKey="Baralle, M" uniqKey="Baralle M">M Baralle</name></author><author><name sortKey="Buratti, E" uniqKey="Buratti E">E Buratti</name></author><author><name sortKey="Baralle, Fe" uniqKey="Baralle F">FE Baralle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Purdom, E" uniqKey="Purdom E">E Purdom</name></author><author><name sortKey="Simpson, Km" uniqKey="Simpson K">KM Simpson</name></author><author><name sortKey="Robinson, Md" uniqKey="Robinson M">MD Robinson</name></author><author><name sortKey="Conboy, Jg" uniqKey="Conboy J">JG Conboy</name></author><author><name sortKey="Lapuk, Av" uniqKey="Lapuk A">AV Lapuk</name></author><author><name sortKey="Speed, Tp" uniqKey="Speed T">TP Speed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morales Garcia, Ja" uniqKey="Morales Garcia J">JA Morales-Garcia</name></author><author><name sortKey="Redondo, M" uniqKey="Redondo M">M Redondo</name></author><author><name sortKey="Alonso Gil, S" uniqKey="Alonso Gil S">S Alonso-Gil</name></author><author><name sortKey="Gil, C" uniqKey="Gil C">C Gil</name></author><author><name sortKey="Perez, C" uniqKey="Perez C">C Perez</name></author><author><name sortKey="Martinez, A" uniqKey="Martinez A">A Martinez</name></author><author><name sortKey="Santos, A" uniqKey="Santos A">A Santos</name></author><author><name sortKey="Perez Castillo, A" uniqKey="Perez Castillo A">A Perez-Castillo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szponar, A" uniqKey="Szponar A">A Szponar</name></author><author><name sortKey="Kovacs, G" uniqKey="Kovacs G">G Kovacs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brouckaert, P" uniqKey="Brouckaert P">P Brouckaert</name></author><author><name sortKey="Libert, C" uniqKey="Libert C">C Libert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massabeau, C" uniqKey="Massabeau C">C Massabeau</name></author><author><name sortKey="Sigal Zafrani, B" uniqKey="Sigal Zafrani B">B Sigal-Zafrani</name></author><author><name sortKey="Belin, L" uniqKey="Belin L">L Belin</name></author><author><name sortKey="Savignoni, A" uniqKey="Savignoni A">A Savignoni</name></author><author><name sortKey="Richardson, M" uniqKey="Richardson M">M Richardson</name></author><author><name sortKey="Kirova, Ym" uniqKey="Kirova Y">YM Kirova</name></author><author><name sortKey="Cohen Jonathan Moyal, E" uniqKey="Cohen Jonathan Moyal E">E Cohen-Jonathan-Moyal</name></author><author><name sortKey="Megnin Chanet, F" uniqKey="Megnin Chanet F">F Megnin-Chanet</name></author><author><name sortKey="Hall, J" uniqKey="Hall J">J Hall</name></author><author><name sortKey="Fourquet, A" uniqKey="Fourquet A">A Fourquet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dennis, G" uniqKey="Dennis G">G Dennis</name></author><author><name sortKey="Sherman, Bt" uniqKey="Sherman B">BT Sherman</name></author><author><name sortKey="Hosack, Da" uniqKey="Hosack D">DA Hosack</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Gao, W" uniqKey="Gao W">W Gao</name></author><author><name sortKey="Lane, Hc" uniqKey="Lane H">HC Lane</name></author><author><name sortKey="Lempicki, Ra" uniqKey="Lempicki R">RA Lempicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soreq, L" uniqKey="Soreq L">L Soreq</name></author><author><name sortKey="Ben Shaul, Y" uniqKey="Ben Shaul Y">Y Ben-Shaul</name></author><author><name sortKey="Israel, Z" uniqKey="Israel Z">Z Israel</name></author><author><name sortKey="Bergman, H" uniqKey="Bergman H">H Bergman</name></author><author><name sortKey="Soreq, H" uniqKey="Soreq H">H Soreq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moran, Lb" uniqKey="Moran L">LB Moran</name></author><author><name sortKey="Graeber, Mb" uniqKey="Graeber M">MB Graeber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lareau, Lf" uniqKey="Lareau L">LF Lareau</name></author><author><name sortKey="Green, Re" uniqKey="Green R">RE Green</name></author><author><name sortKey="Bhatnagar, Rs" uniqKey="Bhatnagar R">RS Bhatnagar</name></author><author><name sortKey="Brenner, Se" uniqKey="Brenner S">SE Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morrison, M" uniqKey="Morrison M">M Morrison</name></author><author><name sortKey="Harris, Ks" uniqKey="Harris K">KS Harris</name></author><author><name sortKey="Roth, Mb" uniqKey="Roth M">MB Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vilardell, J" uniqKey="Vilardell J">J Vilardell</name></author><author><name sortKey="Chartrand, P" uniqKey="Chartrand P">P Chartrand</name></author><author><name sortKey="Singer, Rh" uniqKey="Singer R">RH Singer</name></author><author><name sortKey="Warner, Jr" uniqKey="Warner J">JR Warner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hilleren, P" uniqKey="Hilleren P">P Hilleren</name></author><author><name sortKey="Parker, R" uniqKey="Parker R">R Parker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Jc" uniqKey="Chang J">JC Chang</name></author><author><name sortKey="Kan, Yw" uniqKey="Kan Y">YW Kan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name></author><author><name sortKey="Wilkinson, Mf" uniqKey="Wilkinson M">MF Wilkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ochs, Mj" uniqKey="Ochs M">MJ Ochs</name></author><author><name sortKey="Sorg, Bl" uniqKey="Sorg B">BL Sorg</name></author><author><name sortKey="Pufahl, L" uniqKey="Pufahl L">L Pufahl</name></author><author><name sortKey="Grez, M" uniqKey="Grez M">M Grez</name></author><author><name sortKey="Suess, B" uniqKey="Suess B">B Suess</name></author><author><name sortKey="Steinhilber, D" uniqKey="Steinhilber D">D Steinhilber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, Q" uniqKey="Pan Q">Q Pan</name></author><author><name sortKey="Saltzman, Al" uniqKey="Saltzman A">AL Saltzman</name></author><author><name sortKey="Kim, Yk" uniqKey="Kim Y">YK Kim</name></author><author><name sortKey="Misquitta, C" uniqKey="Misquitta C">C Misquitta</name></author><author><name sortKey="Shai, O" uniqKey="Shai O">O Shai</name></author><author><name sortKey="Maquat, Le" uniqKey="Maquat L">LE Maquat</name></author><author><name sortKey="Frey, Bj" uniqKey="Frey B">BJ Frey</name></author><author><name sortKey="Blencowe, Bj" uniqKey="Blencowe B">BJ Blencowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanner, Cm" uniqKey="Tanner C">CM Tanner</name></author><author><name sortKey="Goldman, Sm" uniqKey="Goldman S">SM Goldman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dorsey, Er" uniqKey="Dorsey E">ER Dorsey</name></author><author><name sortKey="Constantinescu, R" uniqKey="Constantinescu R">R Constantinescu</name></author><author><name sortKey="Thompson, Jp" uniqKey="Thompson J">JP Thompson</name></author><author><name sortKey="Biglan, Km" uniqKey="Biglan K">KM Biglan</name></author><author><name sortKey="Holloway, Rg" uniqKey="Holloway R">RG Holloway</name></author><author><name sortKey="Kieburtz, K" uniqKey="Kieburtz K">K Kieburtz</name></author><author><name sortKey="Marshall, Fj" uniqKey="Marshall F">FJ Marshall</name></author><author><name sortKey="Ravina, Bm" uniqKey="Ravina B">BM Ravina</name></author><author><name sortKey="Schifitto, G" uniqKey="Schifitto G">G Schifitto</name></author><author><name sortKey="Siderowf, A" uniqKey="Siderowf A">A Siderowf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooper, Ta" uniqKey="Cooper T">TA Cooper</name></author><author><name sortKey="Wan, L" uniqKey="Wan L">L Wan</name></author><author><name sortKey="Dreyfuss, G" uniqKey="Dreyfuss G">G Dreyfuss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Licatalosi, Dd" uniqKey="Licatalosi D">DD Licatalosi</name></author><author><name sortKey="Darnell, Rb" uniqKey="Darnell R">RB Darnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lefebvre, S" uniqKey="Lefebvre S">S Lefebvre</name></author><author><name sortKey="Burglen, L" uniqKey="Burglen L">L Burglen</name></author><author><name sortKey="Reboullet, S" uniqKey="Reboullet S">S Reboullet</name></author><author><name sortKey="Clermont, O" uniqKey="Clermont O">O Clermont</name></author><author><name sortKey="Burlet, P" uniqKey="Burlet P">P Burlet</name></author><author><name sortKey="Viollet, L" uniqKey="Viollet L">L Viollet</name></author><author><name sortKey="Benichou, B" uniqKey="Benichou B">B Benichou</name></author><author><name sortKey="Cruaud, C" uniqKey="Cruaud C">C Cruaud</name></author><author><name sortKey="Millasseau, P" uniqKey="Millasseau P">P Millasseau</name></author><author><name sortKey="Zeviani, M" uniqKey="Zeviani M">M Zeviani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author><author><name sortKey="Lotti, F" uniqKey="Lotti F">F Lotti</name></author><author><name sortKey="Dittmar, K" uniqKey="Dittmar K">K Dittmar</name></author><author><name sortKey="Younis, I" uniqKey="Younis I">I Younis</name></author><author><name sortKey="Wan, L" uniqKey="Wan L">L Wan</name></author><author><name sortKey="Kasim, M" uniqKey="Kasim M">M Kasim</name></author><author><name sortKey="Dreyfuss, G" uniqKey="Dreyfuss G">G Dreyfuss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kabashi, E" uniqKey="Kabashi E">E Kabashi</name></author><author><name sortKey="Valdmanis, Pn" uniqKey="Valdmanis P">PN Valdmanis</name></author><author><name sortKey="Dion, P" uniqKey="Dion P">P Dion</name></author><author><name sortKey="Spiegelman, D" uniqKey="Spiegelman D">D Spiegelman</name></author><author><name sortKey="Mcconkey, Bj" uniqKey="Mcconkey B">BJ McConkey</name></author><author><name sortKey="Vande Velde, C" uniqKey="Vande Velde C">C Vande Velde</name></author><author><name sortKey="Bouchard, Jp" uniqKey="Bouchard J">JP Bouchard</name></author><author><name sortKey="Lacomblez, L" uniqKey="Lacomblez L">L Lacomblez</name></author><author><name sortKey="Pochigaeva, K" uniqKey="Pochigaeva K">K Pochigaeva</name></author><author><name sortKey="Salachas, F" uniqKey="Salachas F">F Salachas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sreedharan, J" uniqKey="Sreedharan J">J Sreedharan</name></author><author><name sortKey="Blair, Ip" uniqKey="Blair I">IP Blair</name></author><author><name sortKey="Tripathi, Vb" uniqKey="Tripathi V">VB Tripathi</name></author><author><name sortKey="Hu, X" uniqKey="Hu X">X Hu</name></author><author><name sortKey="Vance, C" uniqKey="Vance C">C Vance</name></author><author><name sortKey="Rogelj, B" uniqKey="Rogelj B">B Rogelj</name></author><author><name sortKey="Ackerley, S" uniqKey="Ackerley S">S Ackerley</name></author><author><name sortKey="Durnall, Jc" uniqKey="Durnall J">JC Durnall</name></author><author><name sortKey="Williams, Kl" uniqKey="Williams K">KL Williams</name></author><author><name sortKey="Buratti, E" uniqKey="Buratti E">E Buratti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vance, C" uniqKey="Vance C">C Vance</name></author><author><name sortKey="Rogelj, B" uniqKey="Rogelj B">B Rogelj</name></author><author><name sortKey="Hortobagyi, T" uniqKey="Hortobagyi T">T Hortobagyi</name></author><author><name sortKey="De Vos, Kj" uniqKey="De Vos K">KJ De Vos</name></author><author><name sortKey="Nishimura, Al" uniqKey="Nishimura A">AL Nishimura</name></author><author><name sortKey="Sreedharan, J" uniqKey="Sreedharan J">J Sreedharan</name></author><author><name sortKey="Hu, X" uniqKey="Hu X">X Hu</name></author><author><name sortKey="Smith, B" uniqKey="Smith B">B Smith</name></author><author><name sortKey="Ruddy, D" uniqKey="Ruddy D">D Ruddy</name></author><author><name sortKey="Wright, P" uniqKey="Wright P">P Wright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name></author><author><name sortKey="Frias, Ma" uniqKey="Frias M">MA Frias</name></author><author><name sortKey="Mele, A" uniqKey="Mele A">A Mele</name></author><author><name sortKey="Ruggiu, M" uniqKey="Ruggiu M">M Ruggiu</name></author><author><name sortKey="Eom, T" uniqKey="Eom T">T Eom</name></author><author><name sortKey="Marney, Cb" uniqKey="Marney C">CB Marney</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Licatalosi, Dd" uniqKey="Licatalosi D">DD Licatalosi</name></author><author><name sortKey="Fak, Jj" uniqKey="Fak J">JJ Fak</name></author><author><name sortKey="Darnell, Rb" uniqKey="Darnell R">RB Darnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, H" uniqKey="Du H">H Du</name></author><author><name sortKey="Cline, Ms" uniqKey="Cline M">MS Cline</name></author><author><name sortKey="Osborne, Rj" uniqKey="Osborne R">RJ Osborne</name></author><author><name sortKey="Tuttle, Dl" uniqKey="Tuttle D">DL Tuttle</name></author><author><name sortKey="Clark, Ta" uniqKey="Clark T">TA Clark</name></author><author><name sortKey="Donohue, Jp" uniqKey="Donohue J">JP Donohue</name></author><author><name sortKey="Hall, Mp" uniqKey="Hall M">MP Hall</name></author><author><name sortKey="Shiue, L" uniqKey="Shiue L">L Shiue</name></author><author><name sortKey="Swanson, Ms" uniqKey="Swanson M">MS Swanson</name></author><author><name sortKey="Thornton, Ca" uniqKey="Thornton C">CA Thornton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, N" uniqKey="Liu N">N Liu</name></author><author><name sortKey="Landreh, M" uniqKey="Landreh M">M Landreh</name></author><author><name sortKey="Cao, K" uniqKey="Cao K">K Cao</name></author><author><name sortKey="Abe, M" uniqKey="Abe M">M Abe</name></author><author><name sortKey="Hendriks, Gj" uniqKey="Hendriks G">GJ Hendriks</name></author><author><name sortKey="Kennerdell, Jr" uniqKey="Kennerdell J">JR Kennerdell</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Wang, Ls" uniqKey="Wang L">LS Wang</name></author><author><name sortKey="Bonini, Nm" uniqKey="Bonini N">NM Bonini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broadway, Jm" uniqKey="Broadway J">JM Broadway</name></author><author><name sortKey="Holtzheimer, Pe" uniqKey="Holtzheimer P">PE Holtzheimer</name></author><author><name sortKey="Hilimire, Mr" uniqKey="Hilimire M">MR Hilimire</name></author><author><name sortKey="Parks, Na" uniqKey="Parks N">NA Parks</name></author><author><name sortKey="Devylder, Je" uniqKey="Devylder J">JE Devylder</name></author><author><name sortKey="Mayberg, Hs" uniqKey="Mayberg H">HS Mayberg</name></author><author><name sortKey="Corballis, Pm" uniqKey="Corballis P">PM Corballis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ray, Cd" uniqKey="Ray C">CD Ray</name></author><author><name sortKey="Burton, Cv" uniqKey="Burton C">CV Burton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bergman, H" uniqKey="Bergman H">H Bergman</name></author><author><name sortKey="Wichmann, T" uniqKey="Wichmann T">T Wichmann</name></author><author><name sortKey="Delong, Mr" uniqKey="Delong M">MR DeLong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hubble, Jp" uniqKey="Hubble J">JP Hubble</name></author><author><name sortKey="Busenbark, Kl" uniqKey="Busenbark K">KL Busenbark</name></author><author><name sortKey="Wilkinson, S" uniqKey="Wilkinson S">S Wilkinson</name></author><author><name sortKey="Penn, Rd" uniqKey="Penn R">RD Penn</name></author><author><name sortKey="Lyons, K" uniqKey="Lyons K">K Lyons</name></author><author><name sortKey="Koller, Wc" uniqKey="Koller W">WC Koller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krauss, Jk" uniqKey="Krauss J">JK Krauss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aouizerate, B" uniqKey="Aouizerate B">B Aouizerate</name></author><author><name sortKey="Martin Guehl, C" uniqKey="Martin Guehl C">C Martin-Guehl</name></author><author><name sortKey="Cuny, E" uniqKey="Cuny E">E Cuny</name></author><author><name sortKey="Guehl, D" uniqKey="Guehl D">D Guehl</name></author><author><name sortKey="Amieva, H" uniqKey="Amieva H">H Amieva</name></author><author><name sortKey="Benazzouz, A" uniqKey="Benazzouz A">A Benazzouz</name></author><author><name sortKey="Fabrigoule, C" uniqKey="Fabrigoule C">C Fabrigoule</name></author><author><name sortKey="Bioulac, B" uniqKey="Bioulac B">B Bioulac</name></author><author><name sortKey="Tignol, J" uniqKey="Tignol J">J Tignol</name></author><author><name sortKey="Burbaud, P" uniqKey="Burbaud P">P Burbaud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malone, Da" uniqKey="Malone D">DA Malone</name></author><author><name sortKey="Pandya, Mm" uniqKey="Pandya M">MM Pandya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soreq, L" uniqKey="Soreq L">L Soreq</name></author><author><name sortKey="Bergman, H" uniqKey="Bergman H">H Bergman</name></author><author><name sortKey="Goll, Y" uniqKey="Goll Y">Y Goll</name></author><author><name sortKey="Greenberg, Ds" uniqKey="Greenberg D">DS Greenberg</name></author><author><name sortKey="Israel, Z" uniqKey="Israel Z">Z Israel</name></author><author><name sortKey="Soreq, H" uniqKey="Soreq H">H Soreq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clark, Ta" uniqKey="Clark T">TA Clark</name></author><author><name sortKey="Sugnet, Cw" uniqKey="Sugnet C">CW Sugnet</name></author><author><name sortKey="Ares, M" uniqKey="Ares M">M Ares</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srinivasan, K" uniqKey="Srinivasan K">K Srinivasan</name></author><author><name sortKey="Shiue, L" uniqKey="Shiue L">L Shiue</name></author><author><name sortKey="Hayes, Jd" uniqKey="Hayes J">JD Hayes</name></author><author><name sortKey="Centers, R" uniqKey="Centers R">R Centers</name></author><author><name sortKey="Fitzwater, S" uniqKey="Fitzwater S">S Fitzwater</name></author><author><name sortKey="Loewen, R" uniqKey="Loewen R">R Loewen</name></author><author><name sortKey="Edmondson, Lr" uniqKey="Edmondson L">LR Edmondson</name></author><author><name sortKey="Bryant, J" uniqKey="Bryant J">J Bryant</name></author><author><name sortKey="Smith, M" uniqKey="Smith M">M Smith</name></author><author><name sortKey="Rommelfanger, C" uniqKey="Rommelfanger C">C Rommelfanger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Da Huang, W" uniqKey="Da Huang W">W da Huang</name></author><author><name sortKey="Sherman, Bt" uniqKey="Sherman B">BT Sherman</name></author><author><name sortKey="Lempicki, Ra" uniqKey="Lempicki R">RA Lempicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Da Huang, W" uniqKey="Da Huang W">W da Huang</name></author><author><name sortKey="Sherman, Bt" uniqKey="Sherman B">BT Sherman</name></author><author><name sortKey="Lempicki, Ra" uniqKey="Lempicki R">RA Lempicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harris, Ma" uniqKey="Harris M">MA Harris</name></author><author><name sortKey="Clark, J" uniqKey="Clark J">J Clark</name></author><author><name sortKey="Ireland, A" uniqKey="Ireland A">A Ireland</name></author><author><name sortKey="Lomax, J" uniqKey="Lomax J">J Lomax</name></author><author><name sortKey="Ashburner, M" uniqKey="Ashburner M">M Ashburner</name></author><author><name sortKey="Foulger, R" uniqKey="Foulger R">R Foulger</name></author><author><name sortKey="Eilbeck, K" uniqKey="Eilbeck K">K Eilbeck</name></author><author><name sortKey="Lewis, S" uniqKey="Lewis S">S Lewis</name></author><author><name sortKey="Marshall, B" uniqKey="Marshall B">B Marshall</name></author><author><name sortKey="Mungall, C" uniqKey="Mungall C">C Mungall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanehisa, M" uniqKey="Kanehisa M">M Kanehisa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmillan, Le" uniqKey="Mcmillan L">LE McMillan</name></author><author><name sortKey="Martin, Ac" uniqKey="Martin A">AC Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Apweiler, R" uniqKey="Apweiler R">R Apweiler</name></author><author><name sortKey="Attwood, Tk" uniqKey="Attwood T">TK Attwood</name></author><author><name sortKey="Bairoch, A" uniqKey="Bairoch A">A Bairoch</name></author><author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name></author><author><name sortKey="Birney, E" uniqKey="Birney E">E Birney</name></author><author><name sortKey="Biswas, M" uniqKey="Biswas M">M Biswas</name></author><author><name sortKey="Bucher, P" uniqKey="Bucher P">P Bucher</name></author><author><name sortKey="Cerutti, L" uniqKey="Cerutti L">L Cerutti</name></author><author><name sortKey="Corpet, F" uniqKey="Corpet F">F Corpet</name></author><author><name sortKey="Croning, Md" uniqKey="Croning M">MD Croning</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Israël</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Soreq, Lilach" sort="Soreq, Lilach" uniqKey="Soreq L" first="Lilach" last="Soreq">Lilach Soreq</name></noRegion><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><name sortKey="Israel, Zvi" sort="Israel, Zvi" uniqKey="Israel Z" first="Zvi" last="Israel">Zvi Israel</name><name sortKey="Soreq, Hermona" sort="Soreq, Hermona" uniqKey="Soreq H" first="Hermona" last="Soreq">Hermona Soreq</name><name sortKey="Soreq, Hermona" sort="Soreq, Hermona" uniqKey="Soreq H" first="Hermona" last="Soreq">Hermona Soreq</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E11 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E11 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3723527
|texte= Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson’s patients leukocytes
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23865419" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |